International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.

Clicks: 385
ID: 58970
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #45 of 485 articles by views in Nature communications

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 485 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5-20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson's disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and expanding GWAS beyond European ancestry populations.
Reference Key
nievergelt2019internationalnature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Nievergelt, Caroline M;Maihofer, Adam X;Klengel, Torsten;Atkinson, Elizabeth G;Chen, Chia-Yen;Choi, Karmel W;Coleman, Jonathan R I;Dalvie, Shareefa;Duncan, Laramie E;Gelernter, Joel;Levey, Daniel F;Logue, Mark W;Polimanti, Renato;Provost, Allison C;Ratanatharathorn, Andrew;Stein, Murray B;Torres, Katy;Aiello, Allison E;Almli, Lynn M;Amstadter, Ananda B;Andersen, Søren B;Andreassen, Ole A;Arbisi, Paul A;Ashley-Koch, Allison E;Austin, S Bryn;Avdibegovic, Esmina;Babić, Dragan;Bækvad-Hansen, Marie;Baker, Dewleen G;Beckham, Jean C;Bierut, Laura J;Bisson, Jonathan I;Boks, Marco P;Bolger, Elizabeth A;Børglum, Anders D;Bradley, Bekh;Brashear, Megan;Breen, Gerome;Bryant, Richard A;Bustamante, Angela C;Bybjerg-Grauholm, Jonas;Calabrese, Joseph R;Caldas-de-Almeida, José M;Dale, Anders M;Daly, Mark J;Daskalakis, Nikolaos P;Deckert, Jürgen;Delahanty, Douglas L;Dennis, Michelle F;Disner, Seth G;Domschke, Katharina;Dzubur-Kulenovic, Alma;Erbes, Christopher R;Evans, Alexandra;Farrer, Lindsay A;Feeny, Norah C;Flory, Janine D;Forbes, David;Franz, Carol E;Galea, Sandro;Garrett, Melanie E;Gelaye, Bizu;Geuze, Elbert;Gillespie, Charles;Uka, Aferdita Goci;Gordon, Scott D;Guffanti, Guia;Hammamieh, Rasha;Harnal, Supriya;Hauser, Michael A;Heath, Andrew C;Hemmings, Sian M J;Hougaard, David Michael;Jakovljevic, Miro;Jett, Marti;Johnson, Eric Otto;Jones, Ian;Jovanovic, Tanja;Qin, Xue-Jun;Junglen, Angela G;Karstoft, Karen-Inge;Kaufman, Milissa L;Kessler, Ronald C;Khan, Alaptagin;Kimbrel, Nathan A;King, Anthony P;Koen, Nastassja;Kranzler, Henry R;Kremen, William S;Lawford, Bruce R;Lebois, Lauren A M;Lewis, Catrin E;Linnstaedt, Sarah D;Lori, Adriana;Lugonja, Bozo;Luykx, Jurjen J;Lyons, Michael J;Maples-Keller, Jessica;Marmar, Charles;Martin, Alicia R;Martin, Nicholas G;Maurer, Douglas;Mavissakalian, Matig R;McFarlane, Alexander;McGlinchey, Regina E;McLaughlin, Katie A;McLean, Samuel A;McLeay, Sarah;Mehta, Divya;Milberg, William P;Miller, Mark W;Morey, Rajendra A;Morris, Charles Phillip;Mors, Ole;Mortensen, Preben B;Neale, Benjamin M;Nelson, Elliot C;Nordentoft, Merete;Norman, Sonya B;O'Donnell, Meaghan;Orcutt, Holly K;Panizzon, Matthew S;Peters, Edward S;Peterson, Alan L;Peverill, Matthew;Pietrzak, Robert H;Polusny, Melissa A;Rice, John P;Ripke, Stephan;Risbrough, Victoria B;Roberts, Andrea L;Rothbaum, Alex O;Rothbaum, Barbara O;Roy-Byrne, Peter;Ruggiero, Ken;Rung, Ariane;Rutten, Bart P F;Saccone, Nancy L;Sanchez, Sixto E;Schijven, Dick;Seedat, Soraya;Seligowski, Antonia V;Seng, Julia S;Sheerin, Christina M;Silove, Derrick;Smith, Alicia K;Smoller, Jordan W;Sponheim, Scott R;Stein, Dan J;Stevens, Jennifer S;Sumner, Jennifer A;Teicher, Martin H;Thompson, Wesley K;Trapido, Edward;Uddin, Monica;Ursano, Robert J;van den Heuvel, Leigh Luella;Van Hooff, Miranda;Vermetten, Eric;Vinkers, Christiaan H;Voisey, Joanne;Wang, Yunpeng;Wang, Zhewu;Werge, Thomas;Williams, Michelle A;Williamson, Douglas E;Winternitz, Sherry;Wolf, Christiane;Wolf, Erika J;Wolff, Jonathan D;Yehuda, Rachel;Young, Ross McD;Young, Keith A;Zhao, Hongyu;Zoellner, Lori A;Liberzon, Israel;Ressler, Kerry J;Haas, Magali;Koenen, Karestan C;
Journal Nature communications
Year 2019
DOI
10.1038/s41467-019-12576-w
URL
Keywords
depression replication neuroticism bifactor measurement models interpersonal functioning

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.