Comparison of 5-aminolevulinic acid and sodium fluorescein for intraoperative tumor visualization in patients with high-grade gliomas: a single-center retrospective study.

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2019
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Abstract
Maximal safe resection is an important surgical goal in the treatment for high-grade gliomas. Fluorescent dyes help the surgeon to distinguish malignant tissue from healthy. The aims of this study were 1) to compare the 2 fluorescent dyes 5-aminolevulinic acid (5-ALA) and sodium fluorescein (fluorescein) regarding extent of resection, progression-free survival, and overall survival; and 2) to assess the influence of other risk factors on clinical outcome and screen for potential disadvantages of the dyes.A total of 209 patients with high-grade gliomas were included in this retrospective study. Resections were performed in the period from 2012 to 2017 using 5-ALA or fluorescein. Extent of resection was assessed as the difference in tumor volume between early postoperative and preoperative MRI studies. Tumor progression-free survival and overall survival were analyzed using an adjusted Cox proportional hazards model.One hundred fifty-eight patients were operated on with 5-ALA and 51 with fluorescein. The median duration of follow-up was 46.7 and 21.2 months, respectively. Covariables were evenly distributed. There was no statistically significant difference in volumetrically assessed median extent of resection (96.9% for 5-ALA vs 97.4% for fluorescein, p = 0.46) or the percentage of patients with residual tumor volume less than 0.175 cm3 (29.5% for 5-ALA vs 36.2% for fluorescein, p = 0.39). The median overall survival was 14.8 months for the 5-ALA group and 19.7 months for the fluorescein group (p = 0.06). The median adjusted progression-free survival was 8.7 months for the 5-ALA group and 9.2 months for the fluorescein group (p = 0.03).Fluorescein can be used as a viable alternative to 5-ALA for intraoperative fluorescent guidance in brain tumor surgery. Comparative, prospective, and randomized studies are much needed.
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Authors Hansen, Rasmus W;Pedersen, Christian B;Halle, Bo;Korshoej, Anders R;Schulz, Mette K;Kristensen, Bjarne W;Poulsen, Frantz R;
Journal journal of neurosurgery
Year 2019
DOI
10.3171/2019.6.JNS191531
URL
Keywords
Cancer asa = american society of anesthesiologists oncology pfs = progression-free survival neurosurgery eor = extent of resection gtr = gross-total resection os = overall survival 5-ala = 5-aminolevulinic acid cret = complete resection of contrast enhancing tumor ecog = eastern cooperative oncology group idh-1 = isocitrate dehydrogenase 1 iqr = interquartile range kps = karnofsky performance score mgmt = o6-methylguanine-methyltransferase pr = partial resection rano = response assessment in neuro-oncology gliomas

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