Pancreatic Fistula after Pancreatectomy: Definitions, Risk Factors, Preventive Measures, and Management—Review

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ID: 58544
2012
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Abstract
Resection of pancreas, in particular pancreaticoduodenectomy, is a complex procedure, commonly performed in appropriately selected patients with benign and malignant disease of the pancreas and periampullary region. Despite significant improvements in the safety and efficacy of pancreatic surgery, pancreaticoenteric anastomosis continues to be the “Achilles heel” of pancreaticoduodenectomy, due to its association with a measurable risk of leakage or failure of healing, leading to pancreatic fistula. The morbidity rate after pancreaticoduodenectomy remains high in the range of 30% to 65%, although the mortality has significantly dropped to below 5%. Most of these complications are related to pancreatic fistula, with serious complications of intra-abdominal abscess, postoperative bleeding, and multiorgan failure. Several pharmacological and technical interventions have been suggested to decrease the pancreatic fistula rate, but the results have been controversial. This paper considers definition and classification of pancreatic fistula, risk factors, and preventive approach and offers management strategy when they do occur.
Reference Key
machado2012pancreaticinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Machado, Norman Oneil;
Journal international journal of surgical oncology
Year 2012
DOI
DOI not found
URL
http://dx.doi.org/10.1155/2012/602478
Keywords
Medicine Science surgery Medical emergencies. Critical care. Intensive care. First aid neoplasms. tumors. oncology. including cancer and carcinogens diseases of the endocrine glands. clinical endocrinology diseases of the digestive system. gastroenterology

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