Synthesis of Fused Bicyclic [1,2,3]-Triazoles from γ-Amino Diazoketones.

Clicks: 127
ID: 58282
2019
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Abstract
Triazoles are an important class of N-heterocycles that are well known for their broad biological activities. In this work, we would like to demonstrate a direct synthesis of the rare fused bicyclic [1,2,3]-triazoles, employing γ--protected amino diazoketones as useful synthetic platforms. The strategy was based on the deprotection of a trifluoroacetamide group for the intramolecular and in situ generation of an α-diazo imine intermediate, followed by a 5--dig cyclization to construct the bicyclic unit. In this fashion, the synthesis of a series of fused bicyclic [1,2,3]-triazoles could be carried out in good to excellent yields (63-95%).
Reference Key
santiago2019synthesisacs Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Santiago, João Victor;Burtoloso, Antonio C B;
Journal ACS omega
Year 2019
DOI
10.1021/acsomega.8b02764
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