Safer Attitude to Risky Decision-Making in Premanifest Huntington’s Disease Subjects

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ID: 58077
2019
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Ranked #453 of 510 articles by views in Frontiers in psychology

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Abstract
Huntington’s disease (HD) is an inherited neurodegenerative disorder characterized by involuntary, jerky movements, incoordination, behavioral changes and subtle executive and cognitive impairment starting before motor symptoms. Our study aimed to assess the risky decision-making process in premanifest (pre) HD subjects, by means Game of Dice Task (GDT). As dependent variables, several GDT outcomes have been taken into consideration. We recruited 30 subjects (15 females) with preHD (i.e., Diagnosis Confidence Level < 4; Total Motor Score < 10), and 21 age, gender and education matched neurologically normal subjects (11 females). GDT is a computer-guided task where subjects are invited to watch the digits on which to bet and to evaluate the related potential risk to win or loss. Our results showed that decision and feedback times were longer in preHD than in neurologically normal group in both disadvantageous and advantageous choices. PreHD subjects provided a greater number of “safe” strategies, taken with longer decision-making time than neurologically normal subjects, showing a reduced propensity to risk. Such behavior, characterized by increased slowness in acting and providing answers, might contribute to delineate a behavioral and cognitive profile in preHD.
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daurizio2019saferfrontiers Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors D’Aurizio, Giulia;Migliore, Simone;Curcio, Giuseppe;Squitieri, Ferdinando;
Journal Frontiers in psychology
Year 2019
DOI
DOI not found
URL
https://www.frontiersin.org/article/10.3389/fpsyg.2019.00846/full
Keywords
psychology

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