Synergistic drug combination effectively blocks Ebola virus infection.

Clicks: 360
ID: 58019
2017
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Popular

Ranked #14 of 31 articles by views in Antiviral research

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Although a group of FDA-approved drugs were previously identified with activity against Ebola virus (EBOV), most of them are not clinically useful because their human blood concentrations are not high enough to inhibit EBOV infection. We screened 795 unique three-drug combinations in an EBOV entry assay. Two sets of three-drug combinations, toremifene-mefloquine-posaconazole and toremifene-clarithromycin-posaconazole, were identified that effectively blocked EBOV entry and were further validated for inhibition of live EBOV infection. The individual drug concentrations in the combinations were reduced to clinically relevant levels. We identified mechanisms of action of these drugs: functional inhibitions of Niemann-Pick C1, acid sphingomyelinase, and lysosomal calcium release. Our findings identify the drug combinations with potential to treat EBOV infection.
Reference Key
sun2017synergisticantiviral Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sun, Wei;He, Shihua;Martínez-Romero, Carles;Kouznetsova, Jennifer;Tawa, Gregory;Xu, Miao;Shinn, Paul;Fisher, Ethan;Long, Yan;Motabar, Omid;Yang, Shu;Sanderson, Philip E;Williamson, Peter R;García-Sastre, Adolfo;Qiu, Xiangguo;Zheng, Wei;
Journal Antiviral research
Year 2017
DOI
10.1016/j.antiviral.2016.11.017
URL
Keywords
drug combination drug repurposing polypharmacology ebola prevention ebola treatment

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.