Design, Synthesis, Antimicrobial Evaluation, and Molecular Modeling Studies of Novel Indolinedione-Coumarin Molecular Hybrids.

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ID: 57966
2019
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Abstract
Keeping in view various pharmacological attributes of indole and coumarin derivatives, a new series of indolindione-coumarin molecular hybrids was rationally designed and synthesized. All synthesized hybrid molecules were evaluated for their antimicrobial potential against Gram-negative bacterial strains ( and ), Gram-positive bacterial strains ( and ), and four fungal strains (, , sp., and ) by using the agar gel diffusion method. Among all synthetics, compounds and were found to be the best antimicrobial agents with the minimum inhibitory concentration values of 30 and 312 μg/mL, against sp. and , respectively. The biological data revealed some interesting facts about the structure-activity relationship which state that the electronic environment on the indolinedione moiety and carbon chain length between indolinedione and triazole moieties considerably affect the antimicrobial potential of the synthesized hybrids. Various types of binding interactions of within the active site of dihydrofolate reductase were also streamlined by molecular modeling studies, which revealed the possible mechanism for potent antibacterial activity of the compound.
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bhagat2019designacs Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Bhagat, Kavita;Bhagat, Jyoti;Gupta, Manish Kumar;Singh, Jatinder Vir;Gulati, Harmandeep Kaur;Singh, Atamjit;Kaur, Kamalpreet;Kaur, Gurinder;Sharma, Shally;Rana, Abhineet;Singh, Harbinder;Sharma, Sahil;Singh Bedi, Preet Mohinder;
Journal ACS omega
Year 2019
DOI
10.1021/acsomega.8b02481
URL
Keywords
antibacterial Triazole pterostilbene mrsa

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