Synthesis of podophyllotoxin-glycosyl triazoles click protocol mediated by silver (I)--heterocyclic carbenes and their anticancer evaluation as topoisomerase-II inhibitors.

Clicks: 450
ID: 57933
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #5 of 83 articles by views in Natural product research

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Herein we report the regioselective synthesis of podophyllotoxin-Glycosyl triazole hybrids catalysed by Ag(I)--heterocyclic carbene (Ag(I)-NHC) in a short reaction time (∼30 min) at ambient conditions. In principle, it is the first report of Click alkyne-azide cycloaddition catalysed by Ag(I)-NHC catalyst and moreover, this new methodology yielded good results when compared with traditional CuAAC in terms of reaction time and selectivity. The synthesised compounds were further explored for anticancer activity against four human cancer cell lines Du145, HeLa, A-549, and MCF-7 and found that these synthesised compounds possess significant anticancer activity. Further, the compounds and were identified as promising leads due to their better activity across all cell lines than that of the standard drug etoposide. Molecular docking studies of 5a & 5e with DNA Topoisomerase-II were revealed that the free energy calculations of active compounds were in good agreement with observed IC values.
Reference Key
nerella2019synthesisnatural Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Nerella, Srinivas;Kankala, Shravankumar;Gavaji, Brahmeshwari;
Journal Natural product research
Year 2019
DOI
10.1080/14786419.2019.1610958
URL
Keywords
Click chemistry ag (nhc) catalyst podophyllotoxin anticancer studies podophyllotoxin-glycosyl triazoles

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.