Coordination-Driven Self-Assembly of Triazole-Based Apoptosis-Inducible Metallomacrocycles.

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ID: 57924
2019
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Abstract
Ru(II)-metallomacrocycles containing 4-pyridyl-1,2,3-triazole moiety were realized by coordination-driven self-assembly. All new compounds were characterized by electrospray ionisation mass spectrometry, elemental analysis, and H and C NMR spectroscopic techniques. The molecular structure of metallomacrocycle was determined by single-crystal X-ray crystallography. The anticancer activities of metallomacrocycles - were evaluated by cytotoxicity, cell cycle analysis, and related protein expression. Metallomacrocycle showed the highest cytotoxicity in HepG2 human hepatocellular carcinoma cells. In addition, apoptotic HepG2 cells were analyzed when metallomacrocycle was treated. Our results suggest that metallomacrocycle induces liver cancer cell death by increasing apoptosis and cell cycle arrest and that it has potential use as an agent for the treatment of human hepatocellular carcinoma.
Reference Key
singh2019coordinationdrivenacs Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Singh, Jatinder;Park, Dae Won;Kim, Dong Hwan;Singh, Nem;Kang, Se Chan;Chi, Ki-Whan;
Journal ACS omega
Year 2019
DOI
10.1021/acsomega.9b00093
URL
Keywords
anticancer oxidative stress reactive oxygen species catalase binary catalyst therapy mn-tetraphenylporphyrin sod1

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