Synthesis of 1H-1,2,3-triazoles and study of their antifungal and cytotoxicity activities.

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2013
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Abstract
We report herein the results of antifungal activity of fifteen 1,2,3-triazoles against Candida albicans, Candida krusei, Candida parapsilosis, Candida kefyr, Candida tropicalis, Candida dubliniensis, Tricophyton rubrum, Microporum canis and Aspergillus niger. All of the 1,2,3-triazoles were prepared from 1,3-dipolar cyclizations between aryl azides and alkynes catalyzed by Cu(I), and several of the compounds exhibited antifungal activity with low cytotoxicity. The results demonstrated the potential and importance of developing new 1,2,3-triazoles compounds with antifungal activity.
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Authors da Silva, Iara F;Martins, Prisicila R C;da Silva, Emanuelly G;Ferreira, Sabrina B;Ferreira, Vitor F;da Costa, Karen Regina C;de Vasconcellos, Marne C;Lima, Emerson S;da Silva, Fernando de C;
Journal medicinal chemistry (shariqah (united arab emirates))
Year 2013
DOI
DOI not found
URL URL not found
Keywords
annulation heterocycles synthetic methods reaction mechanisms rhodium

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