The Anticancer Activity of Cetraria Islandica (L.) Ach in Breast Cancer Cells Through Crosstalk of Ampk-α1 and Erk1/2 Signalling

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ID: 57067
2018
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Abstract
In the present study, we aimed to evaluate the anticancer activities of Cetraria islandica (C.islandica) extracts on MCF-7 breast cancer cell lines. Cell viability, protein levels, apoptotic cells number, F-actin distribution were measured. Cell viability of MCF-7 breast cancer cells was found to be reduced in a dose-dependent manner.EC50 values of C.islandica on MCF-7 cells were found to be 9.2047 E-5 g/ml (cell amount) by using intelligence system. Expressions of p53, caspase 3 and Bcl-2, were shown to be elevated after low doses of extract and diminished after high dose treatments. PPAR- protein level was decreased, although AMP-activated kinases-α1 (AMPK-α1) protein level was increasedin its extract groups. ERK1/2 protein level was also elevated in its extract groups. 125 mg/ml of extract treated cells show a low decrease in actin filament density. MCF-7 cells with C.islandica treatment for 24 h increased the apoptotic cell percentage, though the cells-treated with C.islandica for 48 was high necrotic cells percentage. Consequently, the C.islandica extract treatment causes to elevate ERK1/2 and AMPK-α1 protein levels, resulting in PPAR- and then triggers the apoptosis by modulation caspase-3 and P53 protein levels. Therefore, C.islandica might be a good candidate for anticancer tissue, especially soft tissue tumours.
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guven2018theturkish Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Güven, Celal;Taskın, Eylem;Yumtutas, Onder;Sener, Leyla Turker;Ozay, Yusuf;Dal, Fulya;Ahbab, Mufide;Bozgeyik, Ibrahim;Albeniz, Isil;Bagıs, Haydar;Yıldız, Atilla;
Journal turkish journal of agriculture: food science and technology
Year 2018
DOI
DOI not found
URL
http://www.agrifoodscience.com/index.php/TURJAF/article/view/1940
Keywords
Agriculture (General) neurosciences. biological psychiatry. neuropsychiatry agriculture history of scholarship and learning. the humanities social sciences islam. bahai faith. theosophy, etc. philosophy. psychology. religion

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