Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies.

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ID: 55677
2019
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Abstract
The antipyretic potential of viscosine, a natural product isolated from the medicinal plant , was investigated using yeast-induced pyrexia rat model, and its structure-activity relationship was investigated through molecular docking analyses with the target enzymes cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1). The in vivo antipyretic experiments showed a progressive dose-dependent reduction in body temperatures of the hyperthermic test animals when injected with viscosine. Comparison of docking analyses with target enzymes showed strongest bonding interactions (binding energy -17.34 kcal/mol) of viscosine with the active-site pocket of mPGES-1. These findings suggest that viscosine shows antipyretic properties by reducing the concentration of prostaglandin E in brain through its mPGES-1 inhibitory action and make it a potential lead compound for developing effective and safer antipyretic drugs for treating fever and related pathological conditions.
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muhammad2019viscosineacs Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Muhammad, Akhtar;Khan, Behramand;Iqbal, Zafar;Khan, Amir Zada;Khan, Inamullah;Khan, Kashif;Alamzeb, Muhammad;Ahmad, Nasir;Khan, Khalid;Lal Badshah, Syed;Ullah, Asad;Muhammad, Sayyar;Jan, Muhammad Tariq;Nadeem, Said;Kabir, Nurul;
Journal ACS omega
Year 2019
DOI
10.1021/acsomega.9b01041
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