Multi-functional electrochemiluminescence aptasensor based on resonance energy transfer between Au nanoparticles and lanthanum ion-doped cadmium sulfide quantum dots.

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ID: 54421
2019
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Abstract
Novel lanthanum ion-doped cadmium sulfide quantum dots (CdS:La QDs) were synthesized and characterized by transmission electron microscopy (TEM) and photoluminescence (PL). Based on CdS:La QDs as the electrochemiluminescence (ECL) luminophores, a distance-dependent ECL intensity enhanced or quenched system between CdS:La QDs and gold nanoparticles (Au NPs) was designed. Firstly, ssDNA 1 was linked to the CdS:La QDs modified glassy carbon electrode via amide bond. Then the prepared Au NP-ssDNA 2 conjugates were used to hybridize with ssDNA 1, the surface plasmon resonances (SPR) of Au NPs enhanced ECL intensity (signal on) while Au NPs and CdS:La QDs were separated at a certain distance. Secondly, In the presence of Hg, the oligonucleotide conformation changed from linear chain to hairpin due to the thymine-Hg-thymine (T-Hg-T) base pairs. ECL quenching (signal off) achieved lie in resonance energy transfer (RET) between the CdS:La QDs and the proximal Au NPs at a close distance. Finally, after being incubated with TB, a strong and stable TB-aptamer complex was generated, which led to the release of Au NP-ssDNA 2 conjugates. The ECL signal of the CdS:La QDs was ultimately recovered (signal on again). The "on-off-on" approach was used to detect Hg and TB, sensitively and respectively. The line ranges were 1.00 × 10 -1.00 × 10 mol L and 1.00 × 10 -1.00 × 10 mol L, respectively. The low limits of detection (S/N = 3) were at 3.00 × 10 mol L and 3.00 × 10 mol L. Moreover, the ECL sensor exhibited high selectivity and good stability, and was successfully applied to the detection of TB in real sample.
Reference Key
wang2019multifunctionalanalytica Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wang, Cun;Chen, Min;Wu, Jingling;Mo, Fangjing;Fu, Yingzi;
Journal analytica chimica acta
Year 2019
DOI
S0003-2670(19)30925-0
URL
Keywords
gold nanoparticles lanthanum ion-doped cadmium sulfide quantum dots multi-functional electrochemiluminescence aptasensor resonance energy transfer

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