Manipulating energy migration within single lanthanide activator for switchable upconversion emissions towards bidirectional photoactivation.

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ID: 54414
2019
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Abstract
Reliance on low tissue penetrating UV or visible light limits clinical applicability of phototherapy, necessitating use of deep tissue penetrating near-infrared (NIR) to visible light transducers like upconversion nanoparticles (UCNPs). While typical UCNPs produce multiple simultaneous emissions for unidirectional control of biological processes, programmable control requires orthogonal non-overlapping light emissions. These can be obtained through doping nanocrystals with multiple activator ions. However, this requires tedious synthesis and produces complicated multi-shell nanoparticles with a lack of control over emission profiles due to activator crosstalk. Herein, we explore cross-relaxation (CR), a non-radiative recombination pathway typically perceived as deleterious, to manipulate energy migration within the same lanthanide activator ion (Er) towards orthogonal red and green emissions, simply by adjusting excitation wavelength from 980 to 808 nm. These UCNPs allow programmable activation of two synergistic light-gated ion channels VChR1 and Jaws in the same cell to manipulate membrane polarization, demonstrated here for cardiac pacing.
Reference Key
mei2019manipulatingnature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Mei, Qingsong;Bansal, Akshaya;Jayakumar, Muthu Kumara Gnanasammandhan;Zhang, Zhiming;Zhang, Jing;Huang, Hua;Yu, Dejie;Ramachandra, Chrishan J A;Hausenloy, Derek J;Soong, Tuck Wah;Zhang, Yong;
Journal Nature communications
Year 2019
DOI
10.1038/s41467-019-12374-4
URL
Keywords
chemoselectivity, catalysis, cross-coupling, dft, synthesis

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