DNA-Encoded Macrocyclic Peptide Library.

Clicks: 318
ID: 53699
2019
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Ranked #43 of 139 articles by views in methods in molecular biology (clifton, nj)

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Abstract
DNA-encoded library technology (ELT) is a cutting-edge enabling technology platform for drug discovery. Here we describe how to design and synthesize a macrocyclic DNA-encoded library; how to perform selection, sequencing, and data analysis to identify potential active peptides; and how to synthesize off-DNA peptides to confirm activity. This approach provides an effective tool for pharmaceutical research based on peptides.
Reference Key
zhu2019dnaencodedmethods Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhu, Zhengrong;Shaginian, Alex;Grady, La Shadric C;Davie, Christopher P;Lind, Kenneth;Pal, Sandeep;Thansandote, Praew;Simpson, Graham L;
Journal methods in molecular biology (clifton, nj)
Year 2019
DOI
10.1007/978-1-4939-9504-2_12
URL
Keywords
affinity selection dna-encoded library macrocyclic peptides

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