Immunomodulatory Effects of Fruiting Body Extract and Solid-State-Cultivated Mycelia of .

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ID: 52936
2019
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Abstract
is a rare and valuable medicinal mushroom indigenous to Taiwan. It has traditionally been used to promote good health. This study aimed to explore the immunomodulatory effects of "Leader Deluxe capsule" (LDAC). LDAC is a healthy food product composed of fruiting body extract and solid-state-cultivated mycelia of . Two complementary studies were performed. In the first, LDAC was orally administered to BABL/c female mice for 6 weeks as part of a non-specific immune study. In the second, mice were treated with LDAC for 8 weeks and immunized with ovalbumin (OVA) in a specific immune study. LDAC increased the growth of splenic immune cells and enhanced the activity of macrophages and natural killer cells. It increased the levels of interleukin (IL)-2, interferon (IFN)-γ, serum immunoglobulin (Ig)G, and OVA-IgG, and decreased the levels of IL-4, IL-5, tumor necrosis factor (TNF)-α, serum IgE, and OVA-IgE. Thus, the findings of this study strongly supported the idea that LDAC possesses immunomodulatory activity.
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lin2019immunomodulatorynutrients Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Lin, Liang-Hung;Chi, Ching-Hsin;Zhang, Xiao-Han;Chen, Ying-Ju;Wang, Ming-Fu;
Journal Nutrients
Year 2019
DOI
E2256
URL
Keywords
ige macrophages natural killer cell igg taiwanofungus camphoratus breathing respiratory pompe disease

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