A Pharmacological Overview of Alpinumisoflavone, a Natural Prenylated Isoflavonoid.

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ID: 52775
2019
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Abstract
Over the last decade, several studies demonstrated that prenylation of flavonoids enhances various biological activities as compared to the respective nonprenylated compounds. In line with this, the natural prenylated isoflavonoid alpinumisoflavone (AIF) has been explored for a number of biological and pharmacological effects (therapeutic potential). In this review, we summarize the current information on health-promoting properties of AIF. Reported data evidenced that AIF has a multitherapeutic potential with antiosteoporotic, antioxidant and anti-inflammatory, antimicrobial, anticancer, estrogenic and antiestrogenic, antidiabetic, and neuroprotective properties. However, research on these aspects of AIF is not sufficient and needs to be reevaluated using more appropriate methods and methodology. Further series of studies are needed to confirm these pharmacological effects, and this review should lay the basis for the design of respective investigations. Overall, despite the drawbacks of studies recorded, AIF exhibits a potential as drug candidate.
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ateba2019afrontiers Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ateba, Sylvin Benjamin;Mvondo, Marie Alfrede;Djiogue, Sefirin;Zingué, Stéphane;Krenn, Liselotte;Njamen, Dieudonné;
Journal Frontiers in pharmacology
Year 2019
DOI
10.3389/fphar.2019.00952
URL
Keywords
structure–activity relationship alpinumisoflavone natural product prenylated isoflavonoid therapeutic potential

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