Dietary Acid Load: A Novel Nutritional Target in Overweight/Obese Children with Asthma?

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2019
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Abstract
Obesity has been repeatedly linked to asthma, and several potential mechanisms have been proposed in the etiologies of the obese-asthma phenotype. Considering that lungs play an important role in systemic pH and acid-base regulation, are a key organ in asthma development, and that nutritional inadequacy of several nutrients and high dietary acid load can affect airway inflammation and reactivity, we aimed to test the hypothesis that dietary acid load may be associated with asthma in children. Data on 699 children (52% females), aged 7-12 years, were analyzed. Anthropometric measurements were performed to assess body mass index. Dietary acid load was calculated using potential renal acid load (PRAL) equations from a 24 h dietary recall administrated to children. Adjusted PRAL for total energy intake was applied with the use of the residual method. Lung function and airway reversibility were assessed with spirometry. Asthma was defined by a positive bronchodilation or self-reported medical diagnosis with reported symptoms (wheezing, dyspnea, or dry cough) in the past 12 months. After adjustment for energy intake, sex, age, parent's education level, and physical activity, positive and significant associations were found between asthma and PRAL [odds ratio (OR) = 1.953, 95% CI = 1.024, 3.730) in overweight/obese children. Our findings suggest that dietary acid load might be a possible mechanism in overweight/obese-asthma phenotype development.
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cunha2019dietarynutrients Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Cunha, Pedro;Paciência, Inês;Cavaleiro Rufo, João;Castro Mendes, Francisca;Farraia, Mariana;Barros, Renata;Silva, Diana;Delgado, Luís;Padrão, Patrícia;Moreira, André;Moreira, Pedro;
Journal Nutrients
Year 2019
DOI
E2255
URL
Keywords
obesity asthma pral dietary acid load fiber bragg grating terfenol-d current transformer unbalanced m–z interferometer

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