Computational prediction of lysine acetylation proteome-wide.

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ID: 51433
2013
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Abstract
Several studies have contributed to our knowledge of the enzymology underlying acetylation, including focused efforts to understand the molecular mechanism of substrate recognition by several acetyltransferases; however, conventional experiments to determine intrinsic features of substrate site specificity have proven challenging. In this chapter, I describe in detail a computational method that involves clustering analysis of protein sequences to predict protein acetylation based on the sequence characteristics of acetylated lysines within histones. This method illustrates that sequence composition has predictive power on datasets of acetylation marks, and can be used to predict other posttranslational modifications such as methylation and phosphorylation. Later in this chapter, other recent methods to predict lysine acetylation are described and together, these approaches combined with more traditional experimental methods, can be useful for identifying acetylated substrates proteome-wide.
Reference Key
basu2013computationalmethods Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Basu, Amrita;
Journal methods in molecular biology (clifton, nj)
Year 2013
DOI
10.1007/978-1-62703-305-3_10
URL
Keywords
Cytotoxicity Proteomics systems biology metals risk assessment chemical mixtures chemical interactions dose response mixture toxicity

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