Gamma photon protection properties of some cancer drugs for medical applications

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ID: 51352
2019
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Abstract
Chemotherapy stops or slows down the growth and proliferation of cancer cells. Chemotherapy usually uses in combination with, surgery, radiotherapy or other treatments. Therefore, it is useful to calculate the photon interaction parameters to determine the energy accumulation and penetration in tissue due to the interaction of cancer drugs with radiation. In this work, the mass attenuation coefficient (μ/ρ), half value layer (HVL) and effective atomic number (Zeff) of some cancer drugs (Tadocel, Fluro-5, Erbitux, Carboplatin, Temodal, Tamoxifen, Endoksan and Oxaliplatin) have determined experimentally at 13.81, 17.7, 26.34 and 59.54 keV photons emitted from Am-241-point source by using Si(Li) detector. Besides, we calculated theoretically the gamma-ray interaction parameters using the WinXCOM software program. Next to these, utilizing the GP fitting approach, exposure buildup factors (EBF) of the drugs determined up to 40 mfp in the energy range 0.015–15 MeV. Experimental and theoretical results have been found to be in harmony. Oxaliplatin and Carboplatin have larger μ and Zeff and lower HVL values than the other drugs under study. The smallest EBF values are observed for Endoksan, Oxaliplatin and Carboplatin for all of the penetration depths. Oxaliplatin, carboplatin and endoksan possess significantly good radiation absorbing effect. Keywords: Cancer, Drug, Mass attenuation coefficient, Exposure buildup factor, Photon interactions
Reference Key
yorgun2019gammaresults Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yorgun, Nergiz Yıldız;Kavaz, Esra;
Journal results in physics
Year 2019
DOI
DOI not found
URL
http://www.sciencedirect.com/science/article/pii/S2211379719303742
Keywords
Medical technology physics

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