Elastomeric cardiopatch scaffold for myocardial repair and ventricular support.

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ID: 49394
2019
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Ranked #4 of 44 articles by views in european journal of cardio-thoracic surgery : official journal of the european association for cardio-thoracic surgery

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Abstract
Prevention of postischaemic ventricular dilatation progressing towards pathological remodelling is necessary to decrease ventricular wall deterioration. Myocardial tissue engineering may play a therapeutic role due to its capacity to replace the extracellular matrix, thereby creating niches for cell homing. In this experimental animal study, a biomimetic cardiopatch was created with elastomeric scaffolds and nanotechnologies.In an experimental animal study in 18 sheep, a cardiopatch was created with adipose tissue-derived progenitor cells seeded into an engineered bioimplant consisting of 3-dimensional bioabsorbable polycaprolactone scaffolds filled with a peptide hydrogel (PuraMatrix™). This patch was then transplanted to cover infarcted myocardium. Non-absorbable poly(ethyl) acrylate polymer scaffolds were used as controls.Fifteen sheep were followed with ultrasound scans at 6 months, including echocardiography scans, tissue Doppler and spectral flow analysis and speckle-tracking imaging, which showed a reduction in longitudinal left ventricular deformation in the cardiopatch-treated group. Magnetic resonance imaging (late gadolinium enhancement) showed reduction of infarct size relative to left ventricular mass in the cardiopatch group versus the controls. Histopathological analysis at 6 months showed that the cardiopatch was fully anchored and integrated to the infarct area with minimal fibrosis interface, thereby promoting angiogenesis and migration of adipose tissue-derived progenitor cells to surrounding tissues.This study shows the feasibility and effectiveness of a cardiopatch grafted onto myocardial infarction scars in an experimental animal model. This treatment decreased fibrosis, limited infarct scar expansion and reduced postischaemic ventricular deformity. A capillary network developed between our scaffold and the heart. The elastomeric cardiopatch seems to have a positive impact on ventricular remodelling and performance in patients with heart failure.
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chachques2019elastomericeuropean Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Chachques, Juan Carlos;Lila, Nermine;Soler-Botija, Carolina;Martinez-Ramos, Cristina;Valles, Ana;Autret, Gwennhael;Perier, Marie-Cecile;Mirochnik, Nicolas;Monleon-Pradas, Manuel;Bayes-Genis, Antoni;Semino, Carlos E;
Journal european journal of cardio-thoracic surgery : official journal of the european association for cardio-thoracic surgery
Year 2019
DOI
ezz252
URL
Keywords
heart failure cardiac tissue engineering cardiopatch cardiowrap elastomeric scaffold translational and clinical research

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