Isavuconazole diffusion in infected human brain.

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ID: 4881
2019
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Ranked #62 of 105 articles by views in Antimicrobial agents and chemotherapy

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Abstract
We report cases of a 39-year-old woman with chronic lymphocytic leukemia and of 21-year-old man with chronic granulomatous disease treated for cerebral aspergillosis. Patients required radical surgery respectively for infection progression despite adequate isavuconazole plasma concentration or neurological complication. We thus decided to measure brain isavuconazole concentration. These results suggest that the concentrations of isavuconazole obtained clearly differ in the infected brain tissue from those obtained in the normal brain tissue and the cerebrospinal fluid.
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rouzaud2019isavuconazoleantimicrobial Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rouzaud, Claire;Jullien, Vincent;Herbrecht, Anne;Palmier, Bruno;Lapusan, Simona;Morgand, Marjolaine;Guéry, Romain;Dureault, Amélie;Danion, François;Puget, Stéphanie;Goldwirt, Lauriane;Lanternier, Fanny;Lortholary, Olivier;
Journal Antimicrobial agents and chemotherapy
Year 2019
DOI
AAC.02474-18
URL
Keywords Keywords not found

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