Food derived respiratory complex I inhibitors modify the effect of Leber hereditary optic neuropathy mutations.
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ID: 47946
2018
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Abstract
Mitochondrial DNA mutations in genes encoding respiratory complex I polypeptides can cause Leber hereditary optic neuropathy. Toxics affecting oxidative phosphorylation system can also cause mitochondrial optic neuropathy. Some complex I inhibitors found in edible plants might differentially interact with these pathologic mutations and modify their penetrance. To analyze this interaction, we have compared the effect of rotenone, capsaicin and rolliniastatin-1 on cybrids harboring the most frequent Leber hereditary optic neuropathy mutations and found that m.3460G > A mutation increases rotenone resistance but capsaicin and rolliniastatin-1 susceptibility. Thus, to explain the pathogenicity of mitochondrial diseases due to mitochondrial DNA mutations, their potential interactions with environment factors will have to be considered.
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lpezgallardo2018foodfood
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| Authors | López-Gallardo, Ester;Emperador, Sonia;Hernández-Ainsa, Carmen;Montoya, Julio;Bayona-Bafaluy, M Pilar;Ruiz-Pesini, Eduardo; |
| Journal | food and chemical toxicology : an international journal published for the british industrial biological research association |
| Year | 2018 |
| DOI |
S0278-6915(18)30452-6
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