Food derived respiratory complex I inhibitors modify the effect of Leber hereditary optic neuropathy mutations.

Clicks: 305
ID: 47946
2018
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #19 of 54 articles by views in food and chemical toxicology : an international journal published for the british industrial biological research association

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Mitochondrial DNA mutations in genes encoding respiratory complex I polypeptides can cause Leber hereditary optic neuropathy. Toxics affecting oxidative phosphorylation system can also cause mitochondrial optic neuropathy. Some complex I inhibitors found in edible plants might differentially interact with these pathologic mutations and modify their penetrance. To analyze this interaction, we have compared the effect of rotenone, capsaicin and rolliniastatin-1 on cybrids harboring the most frequent Leber hereditary optic neuropathy mutations and found that m.3460G > A mutation increases rotenone resistance but capsaicin and rolliniastatin-1 susceptibility. Thus, to explain the pathogenicity of mitochondrial diseases due to mitochondrial DNA mutations, their potential interactions with environment factors will have to be considered.
Reference Key
lpezgallardo2018foodfood Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors López-Gallardo, Ester;Emperador, Sonia;Hernández-Ainsa, Carmen;Montoya, Julio;Bayona-Bafaluy, M Pilar;Ruiz-Pesini, Eduardo;
Journal food and chemical toxicology : an international journal published for the british industrial biological research association
Year 2018
DOI
S0278-6915(18)30452-6
URL
Keywords
gene-environment interaction mitochondrial dna xenobiotic leber hereditary optic neuropathy respiratory complex i

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.