Native T1 time and extracellular volume fraction in differentiation of normal myocardium from non-ischemic dilated and hypertrophic cardiomyopathy myocardium: A systematic review and meta-analysis.

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2019
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Abstract
Both native T1 time and extracellular volume (ECV) fraction have been shown to be important measures for the detection of myocardial fibrosis. However, ECV determination requires the administration of an intravenous contrast agent, whereas native T1 mapping can be performed without a contrast agent.Here, we conducted a meta-analysis of myocardial native T1 data obtained for non-ischemic cardiomyopathy (NIC) patients and controls. A literature review included studies that applied T1 mapping using modified Look-Locker inversion recovery to measure myocardial fibrosis, and the results were validated by comparing datasets for dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM) patients and healthy controls (HCs).We identified 16 eligible studies. Pooled mean differences (MDs) and 95% confidence intervals (CIs) were estimated as follows. Native T1 at 1.5-T, DCM vs. HC: MD = 45.26 (95% CI: 30.92-59.59); HCM vs. HC: MD = 47.09 (95% CI: 32.42-61.76). Native T1 at 3.0-T, DCM vs. HC: MD = 82.52 (95% CI: 47.60-117.44); HCM vs. HC: MD = 115.87 (95% CI: 50.71-181.04). ECV at 1.5-T, DCM vs. HC: MD = 4.26 (95% CI: 3.06-5.46); HCM vs. HC: MD = 1.49 (95% CI: -1.45-4.43). ECV at 3.0-T, DCM vs. HC: MD = 8.40 (95% CI: 2.94-13.86); HCM vs. HC: MD = 8.02 (95% CI: 5.45-1-0.59).In conclusion, native T1 values were significantly different between NIC patients and controls. Native T1 mapping may be a useful noninvasive method to detect diffuse myocardial fibrosis in NIC patients.
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minegishi2019nativeinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Shintaro Minegishi, Shingo Kato, Kaoru Takase-Minegishi, Nobuyuki Horita, Kengo Azushima, Hiromichi Wakui, Tomoaki Ishigami, Masami Kosuge, Kazuo Kimura, Kouichi Tamura
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Journal international journal of cardiology heart & vasculature
Year 2019
DOI
10.1016/j.ijcha.2019.100422
URL
Keywords
meta-analysis systematic review SCD, Sudden cardiac death hypertrophic cardiomyopathy dilated cardiomyopathy ci, confidence interval cmr, cardiac magnetic resonance dcm, dilated cardiomyopathy ecv, extracellular volume extracellular volume fraction hc, healthy control hcm, hypertrophic cardiomyopathy lge-mri, late gadolinium-enhanced magnetic resonance imaging md, mean difference minors, methodological index for non-randomized studies molli, modified look-locker inversion recovery nic, non-ischemic cardiomyopathy native t1 mapping sd, standard deviation

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