Effects of oxybutynin transdermal system on health-related quality of life and safety in men with overactive bladder and prostate conditions.

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ID: 47408
2008
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Abstract
Overactive bladder (OAB) is common in men and may exist concomitantly with benign prostatic hyperplasia (BPH) and obstruction. We present a subanalysis of results from men with OAB in a 6-month, open-label study of treatment with the oxybutynin transdermal system (OXY-TDS). Broad entry criteria were incorporated to yield a clinically representative population.All participants received OXY-TDS 3.9 mg/day. Effectiveness was assessed by changes in scores on validated questionnaires, which included the single-item Patient Perception of Bladder Condition (PPBC), the King's Health Questionnaire (KHQ) and the Beck Depression Inventory-II (BDI-II).The proportion of men (n=369; mean age=69.6 years) who reported that their bladder condition caused moderate, severe or many severe problems (PPBC>or=4) improved from 77.3% at baseline to 38.1-53.6% in subsequent months. Mean KHQ scores decreased significantly (p12 (associated with a diagnosis of depression) decreased from 23.9% to 17.9% (p=0.0055). Men with a history of 'prostate problems' or use of 'BPH medication' (32.2%) had KHQ domain changes that were similar (p>or=0.1016) to those of other men. Most men (76.2%) reported no treatment-related adverse events; two men (0.5%) experienced symptoms of mild urinary retention, but neither required catheterisation.Oxybutynin transdermal system treatment of men with OAB was effective and well tolerated, regardless of history of prostate condition.
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staskin2008effectsinternational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Staskin, D R;Rosenberg, M T;Dahl, N V;Polishuk, P V;Zinner, N R;
Journal International Journal of Clinical Practice
Year 2008
DOI
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URL URL not found
Keywords
k-means clustering fcm clustering arterial input function dynamic susceptibility contrast normalized cut clustering

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