Trimethylamine-N-oxide metabolites in the early pregnancy and risk of gestational diabetes: a nested case control study.

Clicks: 513
ID: 4700
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #4 of 44 articles by views in the journal of clinical endocrinology and metabolism

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
This study aimed to investigate the associations between TMAO and related metabolites in the early pregnancy and risk of GDM.A prospective cohort of 22,302 pregnant women from 2010 to 2012 in Tianjin, China, was used to perform a nested case-control study. 243 women with GDM and 243 women without GDM matched with maternal age (+/-1 year) were used as cases and controls respectively. Conditional logistic regression and restricted cubic spline were used to examine the full-range risk associations between individual TMAOs at the first antenatal care visit with GDM. Trimethylamine ratio (TMAR) was defined as TMA/its precursors while TMAO ratio (TMAOR) was defined as TMAO/TMA. An additive interaction between high TMAR and low TMAOR indicates a state of TMA accumulation while a mathematical interaction between high TMAR and high TMAOR indicates accumulation of TMAO.TMA was linearly associated with GDM while TMA precursors and TMAO were inversely associated with GDM with clear threshold effects, i.e., 16 nmol/mL for TMAO, 200 nmol/mL for betaine, 112 nmol/mL for L-carnitine, and 110 and 270 nmol/mL for cholinechloride (a U-shaped relationship). Co-presence of TMAR >0.35 and TMAOR ≤0.15 was associated with markedly higher odds ratio of 11.16 (5.45-22.8), compared to TMAR >0.35 only (1.71, 0.42-6.95) or TMAOR ≤0.15 only (2.06, 1.09-3.90), with a significant additive interaction. However, the mathematical interaction was non-significant.TMAO metabolites in the early pregnancy were associated with the risk of GDM, while TMA was more likely to play a causal role in GDM.
Reference Key
huo2019trimethylaminenoxidethe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Huo, Xiaoxu;Li, Jing;Cao, Yun-Feng;Li, Sai-Nan;Shao, Ping;Leng, Junhong;Li, Weiqin;Liu, Jinnan;Yang, Kai;Ma, Ronald C W;Hu, Gang;Fang, Zhong-Ze;Yang, Xilin;
Journal the journal of clinical endocrinology and metabolism
Year 2019
DOI
jc.2019-00710
URL
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.