Epigallocatechin Exerts Anti-Obesity Effect in Brown Adipose Tissue.

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ID: 46890
2019
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Abstract
Catechins in green tea are well-known to be effective in reducing the risk of obesity. The purpose of this study was to elucidate the effects of catechins present in green tea on adipocyte differentiation and mature adipocyte metabolism. Treatment of 3T3-L1 mouse adipocyte during differentiation adipocytes with (-)-epigallocatechin (EGC) and gallic acid (GA) resulted in dose-dependent inhibition of adipogenesis. Specifically, EGC increased adiponectin and uncoupling protein 1 (UCP1) transcription in mature adipocytes. Transcription levels of adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) were not significantly impacted by either of the compounds. These results suggest that the EGC is the most effective catechin having anti-obesity activity. Finally, EGC is an attractive candidate component for remodeling obesity.
Reference Key
kim2019epigallocatechinchemistry Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kim, Hae-Soo;Jae-Hak, Moon;Kim, Young-Min;Huh, Joo-Young;
Journal Chemistry & biodiversity
Year 2019
DOI
10.1002/cbdv.201900347
URL
Keywords
(−)-epigallocatechin (−)-epigallocatechin gallate anti-obesity gallic acid

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