Targeting NF-κB signaling pathway in cancer by dietary polyphenols.

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ID: 45520
2019
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Abstract
Being a transcription factor, NF-κB regulates gene expressions involving cell survival and proliferation, drug resistance, metastasis, and angiogenesis. The activation of NF-κB plays a central role in the development of inflammation and cancer. Thus, the down-regulation of NF-κB may be an exciting target in prevention and treatment of cancer. NF-κB could act as a tumor activator or tumor suppressant decided by the site of action (organ). Polyphenols are widely distributed in plant species, consumption of which have been documented to negatively regulate the NF-κB signaling pathway. They depress the phosphorylation of kinases, inhibit NF-κB translocate into the nucleus as well as interfere interactions between NF-κB and DNA. Through inhibition of NF-κB, polyphenols downregulate inflammatory cascade, induce apoptosis and decrease cell proliferation and metastasis. This review highlights the anticancer effects of polyphenols on the basis of NF-κB signaling pathway regulation.
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khan2019targetingcritical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Khan, Haroon;Ullah, Hammad;Castilho, Paula Cristina Machado Ferreira;Gomila, Antoni Sureda;D'Onofrio, Grazia;Filosa, Rosanna;Wang, Fang;Nabavi, Seyed Mohammad;Daglia, Maria;Silva, Ana Sanches;Rengasamy, Kannan R R;Ou, Juanying;Zou, Xiaobo;Xiao, Jianbo;Cao, Hui;
Journal critical reviews in food science and nutrition
Year 2019
DOI
10.1080/10408398.2019.1661827
URL
Keywords
Cancer signaling pathway phosphorylation dietary polyphenols nuclear factor-κb

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