Structure and function of the Orc1 BAH-nucleosome complex.

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ID: 45327
2019
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Abstract
The Origin Recognition Complex (ORC) is essential for replication, heterochromatin formation, telomere maintenance and genome stability in eukaryotes. Here we present the structure of the yeast Orc1 BAH domain bound to the nucleosome core particle. Our data reveal that Orc1, unlike its close homolog Sir3 involved in gene silencing, does not appear to discriminate between acetylated and non-acetylated lysine 16, modification states of the histone H4 tail that specify open and closed chromatin respectively. We elucidate the mechanism for this unique feature of Orc1 and hypothesize that its ability to interact with nucleosomes regardless of K16 modification state enables it to perform critical functions in both hetero- and euchromatin. We also show that direct interactions with nucleosomes are essential for Orc1 to maintain the integrity of rDNA borders during meiosis, a process distinct and independent from its known roles in silencing and replication.
Reference Key
de-ioannes2019structurenature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors De Ioannes, Pablo;Leon, Victor A;Kuang, Zheng;Wang, Miao;Boeke, Jef D;Hochwagen, Andreas;Armache, Karim-Jean;
Journal Nature communications
Year 2019
DOI
10.1038/s41467-019-10609-y
URL
Keywords
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