Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas.

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ID: 44837
2019
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Abstract
Layer 4 (L4) of mammalian neocortex plays a crucial role in cortical information processing, yet a complete census of its cell types and connectivity remains elusive. Using whole-cell recordings with morphological recovery, we identified one major excitatory and seven inhibitory types of neurons in L4 of adult mouse visual cortex (V1). Nearly all excitatory neurons were pyramidal and all somatostatin-positive (SOM) non-fast-spiking interneurons were Martinotti cells. In contrast, in somatosensory cortex (S1), excitatory neurons were mostly stellate and SOM interneurons were non-Martinotti. These morphologically distinct SOM interneurons corresponded to different transcriptomic cell types and were differentially integrated into the local circuit with only S1 neurons receiving local excitatory input. We propose that cell type specific circuit motifs, such as the Martinotti/pyramidal and non-Martinotti/stellate pairs, are used across the cortex as building blocks to assemble cortical circuits.
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scala2019layernature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Scala, Federico;Kobak, Dmitry;Shan, Shen;Bernaerts, Yves;Laturnus, Sophie;Cadwell, Cathryn Rene;Hartmanis, Leonard;Froudarakis, Emmanouil;Castro, Jesus Ramon;Tan, Zheng Huan;Papadopoulos, Stelios;Patel, Saumil Surendra;Sandberg, Rickard;Berens, Philipp;Jiang, Xialong;Tolias, Andreas Savas;
Journal Nature communications
Year 2019
DOI
10.1038/s41467-019-12058-z
URL
Keywords
Risk factors Registry evidence-based medicine health care research quality of evidence

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