Effects of superdisintegrants in oral dissolving formulation of cinitapride tablets.

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ID: 44787
2018
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Abstract
The initiation of newer techniques and development of mouth dissolving (MD) products has created new avenues of higher patients' compliance. MD formulations are actually lessen the difficulties associated with solid swallowing with better bioavailability of especially poorly soluble drugs. In the current study mouth dissolving tablet (MDT) formulations of cinitapride (1 mg) were prepared by direct compression method using various proportion and combination of superdisintegrants. Nine formulations in three batches were compressed by incorporating low (2%), intermediate (6%) and higher (10%) levels of crospovidone, croscarmellose sodium, sodium starch glycolate. Micromeritic assessment of the powder blends were carried out and were found within the acceptable official limits. All newly developed trial formulations were exposed to different pharmacopoeial and non-pharmacopoeial testing. It was found that FC2 trial tablets containing polyplasdone XL® (crospovidone) at level of 6% (4.5 mg) presented the best physico-chemical attributes deemed to be desirable for the ODT products. Disintegration and wetting time of optimized FC2 was computed between 15-17 and 12-15 seconds respectively. The assay and content uniformity of FC2 were estimated to be 100.02±0.36 and 99.66±1.70 percent correspondingly. On the basis of the findings it was concluded that MDT could be successfully developed by incorporating appropriate concentration of superdisintegrant and their combinations.
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rehman2018effectspakistan Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rehman, Attaur;Bushra, Rabia;Beg, Anwar Ejaz;Ali, Huma;Zafar, Farya;Ashfaq, Maria;Alam, Shazia;Mustapha, Omer;Shafique, Shumaila;
Journal pakistan journal of pharmaceutical sciences
Year 2018
DOI
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URL URL not found
Keywords
multivariate data analysis benzydamine hydrochloride maltodextrins orodispersible films solvent casting method

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