Formulation design, characterization and optimization of cinitapride (1mg) immediate release tablets using direct compression technology.

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ID: 44781
2018
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Abstract
Cinitapride hydrogen tartarate is relatively a new prokinetic agent that widely prescribed for GERD and epigastric pain. Present study was aimed to develop and optimize cinitapride (1 mg) immediate release (IR) tablet formulation(s) by direct compression using central composite rotatable technique. Overall nine formulations (FC1-FC9) were generated by varying the composition of binder avicel PH 102 (X1) and superdisintegrant crospovidone (X2). The effect of interaction of excipients on hardness (Y1), friability (Y2), disintegration (Y3) and dissolution at 15 min (Y4) were analyzed by RSM plotting. On the basis of physico-chemical evaluation FC3, FC4 and FC6 were found to be the optimized formulations however; FC3 was selected to be the best trial owing to excellent drug release (100.17%) with least friability (0.14%). These IR tablets showed the release pattern similar to the Weibull model with r2 value of 0.978-0.998. The dissimilarity (f1) and similarity indexes (f2) of FC3, FC4, FC6 with the marketed product were estimated to be 2.57 and 76.51, 4.51 and 64.46, 4.32 and 66.78 respectively. Trial optimized formulations were highly stable with the shelf lives of 58-64 months. So, keeping in view the results of present investigation, it is concluded that the technique of manufacturing and optimization is found to be excellent for developing immediate release cinitapride tablets.
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bushra2018formulationpakistan Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Bushra, Rabia;Rehman, Attaur;Ghayas, Sana;Zafar, Farya;Ali, Huma;Shafiq, Yousra;Khalid, Farah;Khan, Maqsood Ahmed;Hanif, Anas;Mustapha, Omer;
Journal pakistan journal of pharmaceutical sciences
Year 2018
DOI
DOI not found
URL URL not found
Keywords
oral bioavailability nanocrystals pickering nanosuspensions nanocrystalline cellulose solid particles stabilizer

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