Free radical sensors based on inner-cutting graphene field-effect transistors.

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ID: 44470
2019
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Abstract
Due to ultra-high reactivity, direct determination of free radicals, especially hydroxyl radical (•OH) with ultra-short lifetime, by field-effect transistor (FET) sensors remains a challenge, which hampers evaluating the role that free radical plays in physiological and pathological processes. Here, we develop a •OH FET sensor with a graphene channel functionalized by metal ion indicators. At the electrolyte/graphene interface, highly reactive •OH cuts the cysteamine to release the metal ions, resulting in surface charge de-doping and a current response. By this inner-cutting strategy, the •OH is selectively detected with a concentration down to 10 M. Quantitative metal ion doping enables modulation of the device sensitivity and a quasi-quantitative detection of •OH generated in aqueous solution or from living cells. Owing to its high sensitivity, selectivity, real-time label-free response, capability for quasi-quantitative detection and user-friendly portable feature, it is valuable in biological research, human health, environmental monitoring, etc.
Reference Key
wang2019freenature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wang, Zhen;Yi, Kongyang;Lin, Qiuyuan;Yang, Lei;Chen, Xiaosong;Chen, Hui;Liu, Yunqi;Wei, Dacheng;
Journal Nature communications
Year 2019
DOI
10.1038/s41467-019-09573-4
URL
Keywords
flexible image sensor low voltage organic electrochemical transistors organic phototransistors volumetric transport

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