Methylenedioxypyrovalerone (MDPV) impairs working memory and alters patterns of dopamine signaling in mesocorticolimbic substrates.

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ID: 4220
2019
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Abstract
Knowledge remains limited about how chronic cathinone exposure impacts dopamine systems in brain reward circuits. In the present study, a binge-like MDPV exposure that impaired novel object recognition (NOR) dysregulated dopamine markers in mesocorticolimbic substrates of rats, with especially profound effects on D1 and D2 receptor's and VMAT gene expression. Our data suggested that dopamine receptivity was reduced in the NAc but increased in the PFC and dopamine-producing VTA. The MDPV-induced impairment of NOR was prevented by a D1 receptor antagonist, suggesting that chronic MDPV exposure produces site-specific dysregulation of dopamine markers in the mesocorticolimbic circuit and memory deficits in the NOR test that are influenced by D1 receptors.
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bernstein2019methylenedioxypyrovaleroneneuroscience Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Bernstein, David L;Nayak, Sunyl U;Oliver, Chicora F;Rawls, Scott M;Rom, Slava;
Journal neuroscience research
Year 2019
DOI
S0168-0102(19)30219-6
URL
Keywords Keywords not found

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