Avocado Oil Extract Modulates Auditory Hair Cell Function through the Regulation of Amino Acid Biosynthesis Genes.

Clicks: 574
ID: 419
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #4 of 376 articles by views in Nutrients

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 376 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Sensorineural hearing loss (SNHL) is one of the most common causes of disability, affecting over 466 million people worldwide. However, prevention or therapy of SNHL has not been widely studied. Avocado oil has shown many health benefits but it has not yet been studied in regards to SNHL. Therefore, we aimed to investigate the efficacy of avocado oil on SNHL in vitro and in vivo and elucidate its mode of action. For the present study, we used enhanced functional avocado oil extract (DKB122). DKB122 led to recovery of otic hair cells in zebrafish after neomycin-induced otic cell damage. Also, DKB122 improved auditory sensory transmission function in a mouse model of noise induced-hearing loss and protected sensory hair cells in the cochlea. In addition, RNA sequencing was performed to elucidate the mechanism involved. KEGG pathway enrichment analysis of differentially expressed genes showed that DKB122 protected House Ear Institute-Organ of Corti 1 (HEI-OC1) cells against neomycin-related alterations in gene expression due to oxidative stress, cytokine production and protein synthesis.
Reference Key
nam2019avocado Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Nam, Youn Hee;Rodriguez, Isabel;Jeong, Seo Yeon;Pham, Thu Nguyen Minh;Nuankaew, Wanlapa;Kim, Yun Hee;Castañeda, Rodrigo;Jeong, Seo Yule;Park, Min Seon;Lee, Kye Wan;Lee, Jung Suk;Kim, Do Hoon;Park, Yu Hwa;Kim, Seung Hyun;Moon, In Seok;Choung, Se-Young;Hong, Bin Na;Jeong, Kwang Won;Kang, Tong Ho;
Journal Nutrients
Year 2019
DOI
E113
URL
Keywords
male infertility assisted reproductive technology kisspeptin neurokinin tachykinin

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.