Multi-level logic gate operation based on amplified aptasensor performance.

Clicks: 127
ID: 40390
2015
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Ranked #186 of 192 articles by views in angewandte chemie (international ed in english)

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Abstract
Conventional electronic circuits can perform multi-level logic operations; however, this capability is rarely realized by biological logic gates. In addition, the question of how to close the gap between biomolecular computation and silicon-based electrical circuitry is still a key issue in the bioelectronics field. Here we explore a novel split aptamer-based multi-level logic gate built from INHIBIT and AND gates that performs a net XOR analysis, with electrochemical signal as output. Based on the aptamer-target interaction and a novel concept of electrochemical rectification, a relayed charge transfer occurs upon target binding between aptamer-linked redox probes and solution-phase probes, which amplifies the sensor signal and facilitates a straightforward and reliable diagnosis. This work reveals a new route for the design of bioelectronic logic circuits that can realize multi-level logic operation, which has the potential to simplify an otherwise complex diagnosis to a "yes" or "no" decision.
Reference Key
feng2015multilevelangewandte Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Feng, Lingyan;Lyu, Zhaozi;Offenhäusser, Andreas;Mayer, Dirk;
Journal angewandte chemie (international ed in english)
Year 2015
DOI
10.1002/anie.201502315
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Keywords Keywords not found

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