Development and optimization of pH-responsive PLGA-chitosan nanoparticles for triggered release of antimicrobials.

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ID: 39300
2019
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Abstract
The aim of this work was to develop and optimize a pH-responsive nanoparticle based on poly(D,L-lactide-co-glycolide) (PLGA) and chitosan (CHIT) for delivery of natural antimicrobial using trans-cinnamaldehyde (TCIN) as a model compound. The optimization was performed using a central composite design and the desirability function approach. The optimized levels of variables considering all significant responses were 4% (w/w) of TCIN and 6.75% (w/w) of CHIT. After, optimized nanoparticles were produced and characterized according to their physicochemical properties and their antimicrobial activity against Salmonella Typhimurium and Staphylococcus aureus. Optimized nanoparticles characterization indicated a satisfactory TCIN encapsulation (33.20 ± 0.85%), spherical shape, pH-responsive controlled release, with faster release in the presence of CHIT at low pH, and enhanced antimicrobial activity against both pathogens. TCIN encapsulation using PLGA coated with CHIT enhanced its antimicrobial activity and generated a delivery system with pH-sensitivity for controlled release with promising properties for food safety applications.
Reference Key
pola2019developmentfood Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Pola, Cícero C;Moraes, Allan R F;Medeiros, Eber A A;Teófilo, Reinaldo F;Soares, Nilda F F;Gomes, Carmen L;
Journal Food chemistry
Year 2019
DOI
S0308-8146(19)30978-1
URL
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