Pregnancy duration and endometrial cancer risk: nationwide cohort study.

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ID: 37165
2019
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Abstract
To explore the association between pregnancy duration and risk of endometrial cancer.Nationwide register based cohort study.Denmark.All Danish women born from 1935 to 2002.Relative risk (incidence rate ratio) of endometrial cancer by pregnancy number, type, and duration, estimated using log-linear Poisson regression.Among 2 311 332 Danish women with 3 947 650 pregnancies, 6743 women developed endometrial cancer during 57 347 622 person years of follow-up. After adjustment for age, period, and socioeconomic factors, a first pregnancy was associated with a noticeably reduced risk of endometrial cancer, whether it ended in induced abortion (adjusted relative risk 0.53 (95% confidence interval 0.45 to 0.64) or childbirth (0.66, 0.61 to 0.72). Each subsequent pregnancy was associated with an additional reduction in risk, whether it ended in induced abortion (0.81, 0.77 to 0.86) or childbirth (0.86, 0.84 to 0.89). Duration of pregnancy, age at pregnancy, spontaneous abortions, obesity, maternal birth cohort, fecundity, and socioeconomic factors did not modify the results.The risk of endometrial cancer is reduced regardless of whether a pregnancy ends shortly after conception or at 40 weeks of gestation. This reduction in risk could be explained by a biological process occurring within the first weeks of pregnancy, as pregnancies ending in induced abortions were associated with similar reductions in risk as pregnancies ending in childbirth.
Reference Key
husby2019pregnancybmj Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Husby, Anders;Wohlfahrt, Jan;Melbye, Mads;
Journal BMJ
Year 2019
DOI
10.1136/bmj.l4693
URL
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