Novel furan coupled quinoline diamide hybrid scaffolds as potent antitubercular agents: Design, synthesis and molecular modelling.

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ID: 36161
2019
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Abstract
A novel series of 2-[(2-{[2-(furan-2-yl) quinolin-4-yl] carbonyl} hydrazinyl) carbonyl] benzoic acid, -4-oxobut-2-enoic acid and -4-oxobutanoic acids were synthesized and screened for in vitro antitubercular activity.In the present investigation, we describe the synthesis and biological screening of furan C-2 quinoline coupled diamides for antitubercular activity.The mycobacterium tuberculai testing was carried out by MABA method and molecular docking studies were done by open source molecular docking program, Autovina, using Pyrx 0.8 interface.The results revealed that the compounds inhibited the growth of H37Rv strain at concentrations as low as 1.6 to 12 µg/ml. Molecular binding of furan, quinoline and diamide (FQD) derivatives on five targets were good and these compounds fit very well within the binding domain of the target protein.The synthesized FQD derivatives exhibited moderate to good inhibition activity especially compounds 5f, 5b and 8a exhibited very good inhibition activity due to the presence of three different scaffolds, such as INH, phenyl ketobutyric acid and fluoroquinolines. Hybridized molecules might have multiple mode of action / inhibit more than one tubercular target and could pave way for novel drug discovery in the field of tuberculosis.
Reference Key
rajpurohit2019novelmedicinal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rajpurohit, Anantacharya;Devappa, Satyanarayan Nayak;Pathak, Lokesh;Ayyanar, Siva;Rishinaradamangalam, Chidambaram Ramaswamy;Shoorapani, Praveen;
Journal medicinal chemistry (shariqah (united arab emirates))
Year 2019
DOI
10.2174/1573406415666190904124630
URL
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