Finding synergies for the 3Rs - Repeated dose toxicity testing: Report from an EPAA partners' forum.

Clicks: 208
ID: 34655
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #59 of 111 articles by views in regulatory toxicology and pharmacology : rtp

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a Partners' Forum on repeated dose toxicity (RDT) testing to identify synergies between industrial sectors and stakeholders along with opportunities to progress these in existing research frameworks. Although RTD testing is not performed across all industrial sectors, the OECD accepted tests can provide a rich source of information and play a pivotal role for safety decisions relating to the use of chemicals. Currently there are no validated alternatives to repeated dose testing and a direct one-to-one replacement is not appropriate. However, there are many projects and initiatives at the international level which aim to implement various aspects of replacement, reduction and refinement (the 3Rs) in RDT testing. Improved definition of use, through better problem formulation, aligned to harmonisation of regulations is a key area, as is the more rapid implementation of alternatives into the legislative framework. Existing test designs can be optimised to reduce animal use and increase information content. Greater use of exposure-led decisions and improvements in dose selection will be beneficial. In addition, EPAA facilitates sharing of case studies demonstrating the use of Next Generation Risk Assessment applying various New Approach Methodologies to assess RDT.
Reference Key
laroche2019findingregulatory Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Laroche, Charles;Annys, Erwin;Bender, Hans;Botelho, Danielle;Botham, Phil;Brendler-Schwaab, Susanne;Clayton, Rick;Corvaro, Marco;Dal Negro, Gianni;Delannois, Frédérique;Dent, Matt;Desaintes, Christian;Desprez, Bertrand;Dhalluin, Stephane;Hartmann, Andreas;Hoffmann-Doerr, Simone;Hubesch, Bruno;Irizar, Amaia;Manou, Irene;Müller, Boris P;Nadzialek, Stephanie;Prieto, Pilar;Rasenberg, Mike;Roggeband, Rob;Rowan, Tim G;Schutte, Katrin;van de Water, Bob;Westmoreland, Carl;Whelan, Maurice;Wilschut, Annette;Zvonimir, Zvonar;Cronin, Mark T D;
Journal regulatory toxicology and pharmacology : rtp
Year 2019
DOI
S0273-2300(19)30234-X
URL
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.