TAS1R3 biases bone marrow stromal cell fate toward adipogenesis through PLCβ4-p38 signaling

Clicks: 2
ID: 339035
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #73 of 73 articles by views in stem cells international

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
How mesenchymal lineage allocation is regulated by nutrients remains poorly understood. Here, we identify TAS1R3, which has been recognized as a component of taste receptors in the taste buds, as being expressed in bone marrow stromal cells (BMSCs) and as a regulator of BMSC fate. Genetic deletion or pharmacological inhibition of TAS1R3 impaired adipogenic differentiation in primary BMSCs, whereas TAS1R3 overexpression enhanced adipogenesis in a BMSC-derived cell line. Consistent results were observed in a human MSC model, in which TAS1R3 promoted adipogenic differentiation and suppressed osteogenic differentiation. Transcriptomic, pharmacological, and knockdown analyses showed that TAS1R3 promotes adipogenesis through phospholipase C beta 4 (PLCβ4)-dependent p38 mitogen-activated protein kinase (MAPK) activation. In contrast, under osteogenic conditions, TAS1R3 attenuated p38 phosphorylation, reduced alkaline phosphatase activity, and restrained osteogenic differentiation. Together, these findings identify TAS1R3 as a context-dependent regulator of p38 signaling and show that extraoral TAS1R3 signaling directs mesenchymal lineage allocation toward adipogenesis at the expense of osteogenesis.
Reference Key
openalex_W7225397059 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Anna Yoshimura, Takuma Matsubara, William N. Addison, Sen Higashi, Moyuri Inoue, Osamu Kaminuma, Hiroshi Takeuchi, Shoichiro Kokabu
Are you one of these authors? Claim your profile
Journal stem cells international
Year 2026
DOI
10.1093/stmcls/sxag059
URL
https://doi.org/10.1093/stmcls/sxag059
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.