Determinants of prostate-specific antigen levels in African men

Clicks: 7
ID: 339029
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #78 of 78 articles by views in jnci cancer spectrum

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
BACKGROUND: Prostate-specific antigen (PSA) is widely used for screening and diagnosis of prostate cancer (CaP). Variation in PSA levels is influenced by age, genetics and other factors, yet this variation has not been well characterized in African men. METHODS: We used data on serum PSA extracted from medical records from prostate cancer cases and controls collected as part of the Men of African Descent and Carcinoma of the Prostate (MADCaP) network. We evaluate the association of PSA levels with country of origin, age, body mass index (BMI), and polygenic risk score (PRS). RESULTS: The median PSA levels were 41.8 (0.2-9696) ng/ml in 1,907 prostate cancer cases and 1.235 (0.01-9.72) ng/ml in 902 controls. Higher PSA levels were associated with increasing age, lower BMI, higher Gleason Score, and more advanced tumor stage in cases, explaining approximately 35% of variation in log-transformed PSA levels. In controls, 4.8% of PSA variation was explained by age. CONCLUSION: Our data in African men are consistent with non-African studies that report PSA levels increase with age, inversely with BMI (suggesting a PSA dilution effect or reverse causation), and with more aggressive disease in cases. These data may be used to help understand PSA distributions and in the future may guide screening practices in African men.
Reference Key
openalex_W7225393388 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Eunsoo Cho, Ilir Agalliu, Thomas E. Rohan, Alfred I. Neugut, Shakuntala Baichoo, Ianne Holanda Lauder, Akkshaya Rajesh, HO Ajibola, Oseremen Inokhoife Aisuodionoe-Shadrach, Pedro W. Fernandez, Abraham C. van Wyk, James Edward Mensah, Andrew A. Adjei, Afua Owusua Darkwah Abrahams, Marjorie Ntiwaa Quarchie, Akindele Olupelumi Adebiyi, Sikiru Adekola Adebayo, Olufemi John Ogunbiyi, Mohamed Jalloh, Nana Yaa Snyper, Ben Adusei, Joseph Lachance, Timothy Richard Rebbeck
Are you one of these authors? Claim your profile
Journal jnci cancer spectrum
Year 2026
DOI
10.1093/jncics/pkag087
URL
https://doi.org/10.1093/jncics/pkag087
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.