The UCSC Genome Browser database: 2027 update

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ID: 338821
2026
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Abstract
Since 2000, the UCSC Genome Browser (https://genome.ucsc.edu) has served as a standard tool for visualizing and comparing annotations across thousands of genome assemblies. Users can browse and visualize a wide range of data types from gene annotations to regulatory regions and comparative genome alignments. Once the data view is configured, the Genome Browser image can be exported for use in publications. Beyond visualization, users can use our tools to compare and export the annotations for further analysis. This year's feature updates include the full release of a tool to copy annotations between related assemblies, QuickLift; feature additions to our data-hosting service HubSpace to enable live editing of configuration files; two new display configurability options: "My Annotations" and custom item coloring; and several improvements to genome assembly discovery and track management. Beyond these new features, 28 new annotation tracks have been added across three broad categories: variant databases and interpretation, gene regulation, and transcriptome and gene expression. These include ENCODE4 cCREs and other ENCODE4 regulatory annotations, variant frequencies and phased variants from national sequencing projects, and two massively parallel reporter assay tracks.
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Authors Matthew L Speir, Marijke J. van Baren, Galt P Barber, Anna Benet‐Pagès, Johannes A. Birgmeier, Jonathan D. Casper, Hiram Clawson, Mark Diekhans, Clay Fischer, Jairo Navarro Gonzalez, Angie S. Hinrichs, Christopher M. Lee, Luis R Nassar, Gerardo Perez, Brian J. Raney, James Robinson, Andrew D Smith, Eliza Alde, Barali Kitiyakara, David H. Haussler, William James Kent, Maximilian Haeussler
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Journal Nucleic Acids Research
Year 2026
DOI
10.1093/nar/gkag1115
URL
https://doi.org/10.1093/nar/gkag1115
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