Phenome-wide Longitudinal Association Study of Hospital-recorded Comorbidity in Psoriasis

Clicks: 4
ID: 338033
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #411 of 411 articles by views in the british journal of dermatology

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 411 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
BACKGROUND: International guidelines recommend screening individuals with psoriasis, a common chronic inflammatory skin condition, for a range of conditions across the spectrum of human disease. Despite this, gaps may remain within our knowledge of the full breadth of comorbidity in psoriasis. OBJECTIVES: To perform a phenome-wide longitudinal association study of psoriasis and its comorbidities. METHOD: We conducted cohort studies (matched for age, sex and general practice) for each block (group of related conditions) of outcomes within the International Classification of Diseases - Clinical Modification (10th ed.) using Clinical Practice Research Datalink Aurum primary care data linked to secondary care Hospital Episode Statistics (to define ICD outcomes) within the United Kingdom. We evaluated the association between psoriasis and outcomes in the first year of diagnosis and in the subsequent period. We estimated hazard ratios (HR) with 99% confidence intervals from Cox regression, with covariate models adjusted for alcohol, smoking, BMI and measures of social deprivation. RESULTS: We compared 320,220 individuals with psoriasis to 1,706,424 matched individuals. In 225 ICD blocks evaluated, psoriasis was associated with numerous outcomes across organ systems. Strong, non-dermatological associations in the long-term included liver disease (HR 1.47 [1.42-1.51], RD 1.16), substance (including alcohol and tobacco) misuse (HR 1.26 [1.25-1.28], RD 3.27) and other respiratory diseases principally affecting the interstitium (HR 1.33 [1.27-1.40], RD 0.31). CONCLUSION: This study provides evidence of association between psoriasis and a range of comorbidity and may serve to generate hypotheses on previously underappreciated associations.
Reference Key
openalex_W7224799600 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Greg Leonard, Abby Emdin, Sheila Mary McSweeney, Catherine H. Smith, Sinéad Langan, Julian Matthewman
Are you one of these authors? Claim your profile
Journal the british journal of dermatology
Year 2026
DOI
10.1093/bjd/ljag450
URL
https://academic.oup.com/bjd/advance-article-pdf/doi/10.1093/bjd/ljag450/72609135/ljag450.pdf
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.