STRAND: a comprehensive subcellular-resolved spatial transcriptome RNA architecture and navigation database

Clicks: 4
ID: 337937
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #1,251 of 1,295 articles by views in Nucleic Acids Research

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 1,295 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Subcellular RNA localization serves as a critical regulatory layer governing cellular polarization, local translation, and functional compartmentalization. Recent advances in high-resolution spatial transcriptomics have provided unprecedented opportunities to resolve these intracellular architectures at single-molecule resolution. However, relevant datasets are dispersed across studies and repositories, vary substantially in processing procedures and standards, severely limiting their cross-study reuse. To bridge this gap, we present STRAND (Subcellular-Resolved Spatial Transcriptome RNA Architecture and Navigation Database), a curated data resource and analysis platform for the automated harvesting, quality control, and interpretation of subcellular spatial transcriptomics data. Through an agent-assisted curation pipeline, STRAND has assembled 35 subcellular-resolution datasets from six major platforms, covering 17 tissue types in human and mouse and totalling ∼4.9 billion transcript coordinates. Building upon this standardized data resource, STRAND provides an analytical workflow spanning cell segmentation evaluation, cell-type annotation, RNA localization/colocalization pattern annotation, and subcellular compartment inference. Two case studies demonstrate that STRAND successfully identifies established RNA localization patterns in cultured cell lines and detects drug-induced RNA relocalization in cardiomyocytes. STRAND is openly available at https://strand.phasep.pro.
Reference Key
openalex_W7224874867 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhaoxu Wu, Yuying Huo, Wenqian Xu, Xiangyu Li, Tingting Li
Are you one of these authors? Claim your profile
Journal Nucleic Acids Research
Year 2026
DOI
10.1093/nar/gkag1054
URL
https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkag1054/72614291/gkag1054.pdf
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.