Loss of PRMT-7 extends lifespan but impairs heat-stress responses in Caenorhabditis elegans

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ID: 337877
2026
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Abstract
Abstract Protein arginine methyltransferase 7 (PRMT-7) contributes approximately 30% of total protein arginine monomethylation in Caenorhabditis elegans. Loss of prmt-7 extended lifespan without affecting brood size. However, prmt-7 mutants showed reduced heat-stress resistance, and transient heat stress did not further extend their lifespan, suggesting distinct roles for PRMT-7 in longevity and heat-stress adaptation.
Reference Key
openalex_W7225014740 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wenyu Zhang, Koichiro Kako, Hiroaki Daitoku, Akiyoshi Fukamizu
Journal bioscience biotechnology and biochemistry
Year 2026
DOI
10.1093/bbb/zbag164
URL
https://doi.org/10.1093/bbb/zbag164
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