Adult inactivation of the Reln gene leads to disruption of cortical lamination and rhythmic activity

Clicks: 12
ID: 337738
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #148 of 151 articles by views in PNAS nexus

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 151 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Cortical cytoarchitecture and lamination are believed to remain stable after completion of development. Here we demonstrate that early postnatal and adult (P45-P60) inactivation of the Reln gene results in dispersion of layer II-III neocortical neurons which invade layer I. In addition, neuronal mispositioning was observed in the dentate gyrus, the CA1-CA3 regions and in the cerebellum. Interestingly, inactivation of the Reln gene at adult stages resulted in altered oscillatory network activity in different cortical regions and in the nucleus accumbens. Moreover, Reelin deficiency increased depression-like behaviour and impaired long-term memory consolidation. Thus, besides its crucial developmental role, Reelin is important in maintaining adult cortical lamination and rhythmic neuronal synchronization. These results suggest that, in addition to physiological and synaptic plasticity, there may be a certain degree of laminar structural plasticity in adult stages, which may lead to reconsidering the origin of layering alterations observed in neuropsychiatric diseases.
Reference Key
openalex_W7224614361 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yasmina Manso, Núria Masachs, Alba Vílchez-Acosta, Victoria González, Gerardo Contreras-Murillo, Raudel Sánchez‐Campusano, Marc Hernaiz-Llorens, Alba Elias-Tersa, María Ángeles Llanos, Gerard Rovira-Escalé, Ana Guerrero, Magdalena Martínez‐Losa, Manuel Álvarez‐Dolado, Jose Maria Delgado-Garcia, Angus Clark Nairn, Agnès Gruart, Eduardo Soriano
Are you one of these authors? Claim your profile
Journal PNAS nexus
Year 2026
DOI
10.1093/pnasnexus/pgag363
URL
https://doi.org/10.1093/pnasnexus/pgag363
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.