Neuronal DNA repair mediates systemic mitochondrial maintenance through acetylcholine signaling

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ID: 334129
2026
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Abstract
DNA repair defects such as nucleotide excision repair (NER) mutations can lead to progeroid syndromes characterized by growth retardation and accelerated aging with distinct tissue type specific pathologies. DNA-damage-induced dysfunction of specific cell types can impair the organism's overall function. It is unknown whether, in reverse, DNA repair in specific tissues can have non-cell-autonomous consequences on other tissues carrying DNA damage. To explore the organismal consequences of cell-type-specific DNA repair, we restricted NER activity to specific tissues and monitored consequences on organismal health in Caenorhabditis elegans. Unexpectedly, we observed that tissue-specific DNA repair is sufficient to improve overall DNA damage resistance. Strikingly, NER activity restricted to neurons only is sufficient to provide similar overall DNA damage resistance as whole-body NER in almost all tissues tested. We show that this systemic DNA damage resilience is mediated by neuronal acetylcholine signaling that promotes the maintenance of mitochondrial activity throughout the organism.
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Authors Paulo F. L. da Silva, Baptiste Ropert, Devin Mares, Matthias Rieckher, Corvin Rive, Björn Schumacher
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Journal Nucleic Acids Research
Year 2026
DOI
10.1093/nar/gkag976
URL
https://doi.org/10.1093/nar/gkag976
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