Dietary Equisetum arvense Polysaccharides Alleviate Obesity in Aged Mice Associated with Altered Gut Microbiota

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ID: 333637
2026
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Abstract
Abstract Equisetum arvense polysaccharides (EAP) represent promising functional nutrients with anti-obesity properties. Using a high fat diet (HFD)-induced obese aging mouse model, this study investigated the anti-obesity efficacy and underlying mechanisms of EAP from the perspective of intestinal microbiota and systemic metabolic networks. Histological assays, biochemical measurements, 16S rRNA gene sequencing, and untargeted metabolomics were adopted to comprehensively detect inflammatory factors, oxidative stress markers, lipid profiles, intestinal flora, and metabolites. The results demonstrated that EAP reduced body weight, alleviated lipid accumulation in hepatic and epididymal adipose tissues, restored lipid homeostasis, recovered the gut microbial diversity impaired by high-fat feeding, and modulated intestinal metabolites. In conclusion, EAP may represent a potential functional dietary ingredient for obesity management.
Reference Key
openalex_W7223407260 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zimo Gao, Hongzhi Sun, Xiaolei Wang, Zhichen Kang, Shiwei Yao, Xinghai Chen
Journal bioscience biotechnology and biochemistry
Year 2026
DOI
10.1093/bbb/zbag159
URL
https://doi.org/10.1093/bbb/zbag159
Keywords Keywords not found

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