Artificial Channels in an Infectious Biofilm Created by Magnetic Nanoparticles Enhanced Bacterial Killing by Antibiotics.

Clicks: 269
ID: 33340
2019
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Abstract
The poor penetrability of many biofilms contributes to the recalcitrance of infectious biofilms to antimicrobial treatment. Here, a new application for the use of magnetic nanoparticles in nanomedicine to create artificial channels in infectious biofilms to enhance antimicrobial penetration and bacterial killing is proposed. Staphylococcus aureus biofilms are exposed to magnetic-iron-oxide nanoparticles (MIONPs), while magnetically forcing MIONP movement through the biofilm. Confocal laser scanning microscopy demonstrates artificial channel digging perpendicular to the substratum surface. Artificial channel digging significantly (4-6-fold) enhances biofilm penetration and bacterial killing efficacy by gentamicin in two S. aureus strains with and without the ability to produce extracellular polymeric substances. Herewith, this work provides a simple, new, and easy way to enhance the eradication of infectious biofilms using MIONPs combined with clinically applied antibiotic therapies.
Reference Key
quan2019artificialsmall Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Quan, Kecheng;Zhang, Zexin;Chen, Hong;Ren, Xiaoxiang;Ren, Yijin;Peterson, Brandon W;van der Mei, Henny C;Busscher, Henk J;
Journal Small (Weinheim an der Bergstrasse, Germany)
Year 2019
DOI
10.1002/smll.201902313
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